Semiparametric estimation of time-dependent ROC curves for longitudinal marker data
نویسندگان
چکیده
منابع مشابه
Semiparametric estimation of time-dependent ROC curves for longitudinal marker data.
One approach to evaluating the strength of association between a longitudinal marker process and a key clinical event time is through predictive regression methods such as a time-dependent covariate hazard model. For example, a Cox model with time-varying covariates specifies the instantaneous risk of the event as a function of the time-varying marker and additional covariates. In this manuscri...
متن کاملBayesian semiparametric estimation of covariate-dependent ROC curves.
Receiver operating characteristic (ROC) curves are widely used to measure the discriminating power of medical tests and other classification procedures. In many practical applications, the performance of these procedures can depend on covariates such as age, naturally leading to a collection of curves associated with different covariate levels. This paper develops a Bayesian heteroscedastic sem...
متن کاملTime-dependent ROC curves for censored survival data and a diagnostic marker.
ROC curves are a popular method for displaying sensitivity and specificity of a continuous diagnostic marker, X, for a binary disease variable, D. However, many disease outcomes are time dependent, D(t), and ROC curves that vary as a function of time may be more appropriate. A common example of a time-dependent variable is vital status, where D(t) = 1 if a patient has died prior to time t and z...
متن کاملTime dependent ROC curves for the estimation of true prognostic capacity of microarray data.
Microarray data can be used to identify prognostic signatures based on time-to-event data. The analysis of microarrays is often associated with overfitting and many papers have dealt with this issue. However, little attention has been paid to incomplete time-to-event data (truncated and censored follow-up). We have adapted the 0.632+ bootstrap estimator for the evaluation of time-dependent ROC ...
متن کاملConfidence Bands for ROC Curves with Serially Dependent Data
We propose serial correlation robust asymptotic confidence bands for the receiver operating characteristic (ROC) curves estimated by quasi-maximum likelihood in the binormal model. Our simulation experiments confirm that this new method performs fairly well in finite samples. The conventional procedure is found to be markedly undersized in terms of yielding empirical coverage probabilities lowe...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biostatistics
سال: 2004
ISSN: 1465-4644,1468-4357
DOI: 10.1093/biostatistics/kxh013